Changes in Estimated Glomerular Filtration Rate and Prognostication Using 2021 Chronic Kidney Disease Epidemiology Collaboration Estimated Glomerular Filtration Rate Equations Incorporating Cystatin C

Revised equations for estimated glomerular filtration rate (eGFR) were published in 2021 using creatinine (eGFR-Cr) and both cystatin C (eGFR-Cr/CysC). This study aimed to evaluate the prognostic role of eGFR incorporating patients with heart failure (HF). The NZ PEOPLE is a prospective cohort HF. Cystatin immunoassays performed on stored plasma samples. eGFR-Cr eGFR-Cr/CysC calculated. Four-year outcomes (death death/HF hospitalisation) assessed Cox proportional hazards models covariates age, sex, ethnicity, deprivation index, New York Heart Association class, diabetes, HF admission, ischaemic aetiology, blood pressure, log(NT-proBNP), one or eGFR-Cr/CysC. Net reclassification improvement (NRI) was calculated equations. Creatinine available 841 patients. Using vs decreased median (to 57 mL/min [IQR 40–76]). reclassified 35% different chronic kidney disease (CKD) stage compared eGFR-Cr. Both variables independent predictors death hospitalisation multivariable (p<0.001). C-statistics similar each model (0.77–0.78) (0.71) There net accuracy CKD as variable over NRI 0.22 [95% CI 0.14–0.31]; 0.16 0.08–0.24]). an predictor adverse clinical outcome. suggested that prognostication improved by equation. It believed this first assessing impact equation